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Plant Inositol Phosphate Signaling Lab (PIPS Lab)

Publications

2026

Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee. Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis. Journal of Integrative Plant Biology. doi: https://doi.org/10.1111/jipb.70268

Kevin Ritter, Verena Gaugler, Sara Christina Stolze, Riya Ghosh, Akhila Jayamon, Ranjana Yadav, Felix Wollensack, Debabrata Laha, Hirofumi Nakagami, Gabriel Schaaf, Henning Jacob Jessen. Affinity-Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6-PP-InsP5-Binding Proteins in Plants. Advanced science. doi: https://doi.org/10.1002/advs.202524290

2025

Riya Ghosh, Ranjana Yadav, Naga Jyothi Pullagurla, Priyanshi Rana, Debabrata Laha. The expanding landscape of inositol phosphate signaling network in land plants. FEBS Letters. doi: https://doi.org/10.1002/1873-3468.70236

Ranjana Yadav, Guizhen Liu, Priyanshi Rana, Naga Jyothi Pullagurla, Danye Qiu, Henning J Jessen, Debabrata Laha. Conservation of heat stress acclimation by the IPK2-type kinases that control the synthesis of the inositol pyrophosphate 4/6-InsP7 in land plants. PLoS Genetics. DOI: https://doi.org/10.1371/journal.pgen.1011838

Priyanshi Rana, Riya Ghosh, Debabrata Laha. Determination of Steady-State Inositol Phosphate Profile of the Liverwort, Marchantia polymorpha, Using SAX-HPLC. Part of the book series: Methods in Molecular Biology (Inositol phosphates). DOI: 10.1007/978-1-0716-4799-8_5

Priyanka Kataria, Naga Jyothi Pullagurla, Debabrata Laha, Patrick D'Silva. Control of heat and oxidative stress adaptation by the DJ-1 paralogs in Arabidopsis thaliana. Plant Molecular Biology. DOI: 10.1007/s11103-025-01630-5.

Priyanshi Rana, Anjana Edathil Kadangodan, Paulami Koley, Riya Ghosh, Naga Jyothi Pullagurla, Hemant Chandru Naik, Padmabati Mondal, Srimonta Gayen & Debabrata Laha. GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant. Nature Chemical Biology. https://www.nature.com/articles/s41589-025-01961-w

Anuj Shukla, Reshma Gopal, Riya Ghosh, Ankur Chaudhuri, Kanupriya Agrwal, Rahul Tanwar, Henning Jacob Jessen, Debabrata Laha, Ajay Kumar Pandey. The wheat VIH2-3B, a functional PPIP5K controls the localization of fasciclin-like arabinogalactan protein. Advances in Biological Regulation. https://doi.org/10.1016/j.jbior.2025.101103\

2024

Kuheli Chalak, Ranjana Yadav, Guizhen Liu, Priyanshi Rana, Henning J. Jessen, Debabrata Laha. Functional Conservation of the DDP1-type Inositol Pyrophosphate Phosphohydrolases in Land Plant. Biochemistry.

https://pubs.acs.org/doi/10.1021/acs.biochem.4c00458

Naga Jyothi Pullagurla, Supritam Shome, Guizhen Liu, Henning J Jessen, Debabrata Laha. Orchestration of phosphate homeostasis by the ITPK1-type inositol phosphate kinase in the liverwort Marchantia polymorpha. Plant Physiology, https://doi.org/10.1093/plphys/kiae454

2023

N. J. Pullagurla, S. Shome, R. Yadav, D. Laha (2023) ITPK1 regulates jasmonate-controlled root development in Arabidopsis thaliana. Biomolecules, doi:https://doi.org/10.3390/biom13091368

2022

N. P. Laha, R. F. H. Giehl, E. Riemer, D. Qiu, N. J. Pullagurla, R. Schneider, Y. Dhir, R. Yadav, Y. Mihiret, P. Gaugler, V. Gaugler, H. Mao, N. Zheng, N. von Wirén, A. Saiardi, S. Bhattacharjee, H.J. Jessen, D. Laha*, G. Schaaf* (2022) INOSITOL (1,3,4) TRIPHOSPHATE 5/6 KINASE1-Dependent Inositol Polyphosphates Regulate Auxin Responses in Arabidopsis. Plant Physiology DOI: 10.1093/plphys/kiac425 (* corresponding author)

E. Riemer*, N. J. Pullagurla, R. Yadav, P. Rana, H. J. Jessen, M. Kamleitner, G. Schaaf, D. Laha* (2022) Regulation of plant biotic interactions and abiotic stress responses by inositol polyphosphates. Frontiers in Plant Science DOI: 10.3389/fpls.2022.944515.

S. Sahoo, D. Singh, A. Singh, M. Pandit, K. Vasu, S. Som, N. J. Pullagurla, D. Laha, S. M. Eswarappa (2022) Identification and functional characterization of mRNAs that exhibit stop codon readthrough in Arabidopsis thaliana. Journal of Biological Chemistry DOI: 10.1016/j.jbc.2022.102173.

P. Gaugler, R. Schneider, G. Liu, D. Qiu, J. Weber, J. Schmid, N. Jork, M. Häner, K. Ritter, N. Fernández-Rebollo, R. F. H. Giehl, M. N. Trung, R. Yadav, D. Fiedler, V.Gaugler, H.J.Jessen, G. Schaaf*, and D. Laha* (2022) Arabidopsis PFA-DSP-Type Phosphohydrolases Target Specific Inositol Pyrophosphate Messengers. Biochemistry DOI: 10.1021/acs.biochem.2c00145.

2021

H. Gulabani, K. Goswami, Y. Walia, A. Roy, J. J. Noor, K. D. Ingole, M. Kasera, D. Laha, R. F. H. Giehl, G. Schaaf & S. Bhattacharjee (2021) Arabidopsis inositol polyphosphate kinases IPK1 and ITPK1 modulate crosstalk between SA-dependent immunity and phosphate-starvation responses. Plant Cell Rep. doi.org/10.1007/s00299-021-02812-3.

E. Riemer, D. Qiu, D. Laha, R. K. Harmel, P. Gaugler, V. Gaugler, M. Frei, M. Hajirezaei, N. Parvin Laha, L. Krusenbaum, R. Schneider, A. Saiardi, D. Fiedler, H. J. Jessen, G. Schaaf, R. F.H. Giehl (2021) ITPK1 is an InsP6/ADP phosphotransferase that controls phosphate signaling in Arabidopsis. Molecular Plant ISSN 1674-2052 doi.org/10.1016/j.molp.2021.07.011.

D. Laha, M. Kamleitner, P. Johnen, G. Schaaf (2021) Analyses of Inositol Phosphates and Phosphoinositides by Strong Anion Exchange (SAX)-HPLC). Plant Lipids. Part of the Methods in Molecular Biology (MIMB, volume 2295)

2020 and Before

D. Laha, P. P. Torres, Y. Desfougères, A. Saiardi (2020) Inositol phosphate kinases in the eukaryote landscape. Adv Biol Regul. doi:10.1016/j.jbior.2020.100782.

Y. Desfougères, M. S. C Wilson, D. Laha, G. Miller, A. Saiardi (2019) ITPK1 Mediates the Lipid-Independent Synthesis of Inositol Phosphates Controlled by Metabolism. Proc Natl Acad Sci USA116(49):24551-24561.

D. Laha*, N. Parvin, A. Hofer, R. Giehl, N. F. Rebollo, N. von Wirén, A. Saiardi, H. J. Jessen, G. Schaaf* (2019) Arabidopsis ITPK1 and ITPK2 Have an Evolutionarily Conserved Phytic Acid Kinase Activity. ACS Chem Biol. 14(10):2127-2133. (*corresponding authors)

Q. Zhang, R. van Wijk, M. Shahbaz, W. Roels, B. van Schooten, J. Vermeer, X. Zarza, A. Guardia, D. Scuffi, C. García-Mata, D. Laha, P. Williams, L. Willems, W. Ligterink, S. Hoffmann-Benning, G. Gillaspy, G. Schaaf, M. Haring, A. Laxalt, T. Munnik (2018) Arabidopsis Phospholipase C3 is Involved in Lateral Root Initiation and ABA Responses in Seed Germination and Stomatal Closure. Plant Cell Physiol. 59: 469-486.

D. Blüher*, D. Laha*, S. Thieme, A. Hofer, L. Eschen-Lippold, A. Masch, G. Balcke, I. Pavlovic, O. Nagel, A. Schonsky, R. Hinkelmann, J. Wörner, N. Parvin, R. Greiner, S. Weber, A. Tissier, M. Schutkowski, J. Lee, H. J. Jessen, G. Schaaf, U. Bonas (2017) A 1-phytase type III effector interferes with plant hormone signaling. Nature Communications 8:2159.doi:10.1038/s41467-017-02195-8. (*equally contributing first authors)

N. Parvin, C. Carrie, I. Pabst, A. Läßer, D. Laha, M. Paul,P. Geigenberger, R. Heermann, K. Jung, U. Vothknecht, F. Chigri (2017) TOM9. 2 Is a calmodulin binding protein critical for TOM complex assembly but not for mitochondrial protein import in Arabidopsis thaliana. Molecular Plant 10: 575-589.

D. Laha*, N. Parvin*, M. Dynowski, P. Johnen, H. Mao, S.T. Bitters, N. Zheng, G. Schaaf (2016) Inositol polyphosphate binding specificity of the jasmonate receptor complex. Plant Physiology 171: 2364-370. (*equally contributing first authors)

D. Laha, P. Johnen, C. Azevedo, M. Dynowski, M. Weiß, S. Capolicchio, T. Iven, M. Steenbergen, M. Freyer, P. Gaugler, M. K. F. de Campos, N. Zheng, I. Feussner, H. J. Jessen, S. C. M. Van Wees, A. Saiardi, G. Schaaf (2015) VIH2 controls biosynthesis of the Inositol Pyrophosphate InsP8 and Regulates the Wound Response in Arabidopsis thaliana. The Plant Cell 27. 1082-1097.

I. Pavlovic, D. T. Thakor, L. Bigler, M.S.C. Wilson, D. Laha, G. Schaaf, A. Saiardi, H. J. Jessen (2015) Prometabolites of 5-diphospho-myo-inositol pentakisphosphate. Angew. Chem. Int. Ed. 54: 9622-26.

Book Chapter

D. Laha (2017) Functional Characterization of Inositol Pyrophosphates in arabidopsis Shaker Verlag GmbH,Germany. ISBN: 978-3-8440-5493-4.

Preprints

Y. Walia, M. Kasera, K. D Ingole, S. Peddiraju, A. Roy, D. Laha, G. Schaaf, S. Bhattacharjee (2020) Arabidopsis inositol polyphosphate kinases regulate COP9 signalosome deneddylase functions in phosphate homeostasis. bioRvix 10.02.323584.

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